Comparative Effectiveness Research

Patients today are faced with more choices—regarding procedures, tests, medications, and devices—than ever before.

Not only do these numerous and complex choices come with increasingly high costs, but the potential benefits and harms of screening and treatment options are not always well understood. Through our program of comparative effectiveness research, we’re producing the evidence that patients, providers, and health systems need to make informed medical and policy decisions. Our pursuit of this evidence includes systematic reviews of previous trials as well as innovative new studies in a wide range of research areas, including:

  • Alcohol Use and Abuse
  • Asthma Epidemiology
  • Breast Cancer Treatment and Prevention
  • Cardiovascular Risk Factors
  • Chronic Kidney Disease
  • Complementary and Alternative Treatments
  • Dental Care Delivery
  • Diabetes
  • Drug Safety and Effectiveness
  • Health Disparities
  • Hypertension
  • Kidney Disease
  • Obesity-related Diseases
  • Tobacco Control
  • Weight Loss
  • Youth Depression

Much of our comparative effectiveness research takes place under the umbrella of the Kaiser Permanente Center for Effectiveness and Safety Research (CESR). Launched in 2009, CESR consists of researchers, health-care providers, data managers, and analysts in all seven of Kaiser Permanente’s regional research centers. This large-scale network, made possible by our Virtual Data Warehouse, gives CHR investigators a platform for investigating both rare events and population-level health issues.

Featured Studies

Press Release

Most Patients with Chronic Pain Use Alternative Therapies, But Many Don’t Tell Their Doctors

More than half of chronic pain patients in a managed care setting reported using chiropractic care or acupuncture or both, but many of these patients didn’t discuss this care with their primary care providers. These study results, published today in The American Journal of Managed Care, suggest that better care coordination is needed among patients and physicians.