Behavior change and wellness research at CHR focuses on areas such as tobacco use, substance abuse, weight loss, nutrition, physical activity, and the workplace. Interventions span a wide spectrum of styles. Many are clinically or community based, while others offer guided self-help programs using the Internet. We also coordinate large multi-center health behavior trials and study the return-on-investment of alternative health strategies and delivery methods. Increasingly in the last decade, CHR researchers have focused on complementary and integrative treatments to aid individuals in changing behavior and maintaining those changes.