ResearchOur PeopleMichael Leo

Michael C. Leo, PhD

Michael Leo, PhD, is a member of the Center for Health Research’s Biostatistics Core. He is a consulting biostatistician and co-investigator on projects that employ a variety of research designs, including quasi-experimental, observational (longitudinal and cross-sectional), community-based participatory, and clinical trial-based (cluster and individually randomized). He is experienced with a variety of statistical techniques, such as general and generalized linear models, structural equation modeling, hierarchical linear modeling, risk model development and validation, interrater agreement, and psychometrics.

At CHR, Dr. Leo has been a co-investigator on studies such as weight loss trials in obese pregnant women and low-income Hispanics, the use of whole genome sequencing for carrier testing, the effectiveness of internet-delivered cognitive behavioral therapy (CBT) for treating depression, and the validation of risk prediction models for prostate and bladder cancer. He was also part of a large multi-site trial that evaluated the effectiveness of xylitol for reducing caries and the data coordinating center for the Community Health Applied Research Network.

Before joining CHR, Dr. Leo was an assistant professor in the Oregon Health & Science University School of Nursing's Statistical Consulting Group, where he taught quantitative research design and analysis in the nursing PhD program. His research at OHSU included cancer-related studies encompassing chemotherapy treatment in children with acute lymphoblastic leukemia, clinical trials of exercise programs in breast and prostate cancer survivors, and other cancer treatment and prevention research. He was a co-investigator on studies in palliative care, fibromyalgia, depression, ADHD, worksite wellness interventions, and others.

Dr. Leo received his PhD from Portland State University in systems science in industrial and organizational psychology and quantitative methods. He earned his master’s degree in industrial and organizational psychology from the University of Tulsa, and a bachelor's degree in economics and psychology from Binghamton University.

Selected Current Studies

  • An Efficacy-Effectiveness Trial of Cognitive Bias Modification for Youth Anxiety (NIMH)
  • Participatory Research to Advance Colon Cancer Prevention (NICHD)
  • Exome Sequencing in Diverse Populations in Colorado & Oregon (NHGRI)
  • Predicting and Addressing Colonoscopy Non-Adherence in Community Settings (NCI)
  • Naturalistic Experiment Evaluating the Impact of Medicaid Treatment Reimbursement Changes on Opioid Prescribing and Patient Outcomes Among Patients with Low Back Pain (PCORI)
  • National Dental Practice-Based Research Network: Coordinating Center (NIDCR)
  • Multi-Site Study of Molecular Markers in Relation to Risk of Recurrence after Breast-Conserving Surgery for DCIS (Prelude Corp.)

Selected Publications

  • Sellmaier C, Leo MC, Brennan EM, Kendall J, Houck GM. Finding fit between work and family responsibilities when caring for children with ADHD diagnoses. J Child Fam Stud 2016 Dec;25(12):3684-933.
  • Amendola LM, Jarvik GP, Leo MC, McLaughlin HM, Akkari Y, Amaral MD, Berg JS, Biswas S, Bowling KM, Conlin LK, Cooper GM, Dorschner MO, Dulik MC, Ghazani AA, Ghosh R, Green RC, Hart R, Horton C, Johnston JJ, Lebo MS, Milosavljevic A, Ou J, Pak CM, Patel RY, Punj S, Richards CS, Salama J, Strande NT, Yang Y, Plon SE, Biesecker LG, Rehm HL. Performance of ACMG-AMP Variant-Interpretation Guidelines among Nine Laboratories in the Clinical Sequencing Exploratory Research Consortium. Am J Hum Genet 2016 Jun 2;98(6):1067-76. PMCID: PMC4908185
  • Fellows JL, Mularski RA, Leo MC, Bentz CJ, Waiwaiole LA, Francisco MC, Funkhouser K, Stoney CM. Referring Hospitalized Smokers to Outpatient Quit Services: A Randomized Trial. Am J Prev Med 2016 Oct;51(4):609-19. PMCID: PMC5031367
  • Vesco KK, Leo MC, Karanja N, Gillman MW, McEvoy CT, King JC, Eckhardt CL, Smith KS, Perrin N, Stevens VJ. One-year postpartum outcomes following a weight management intervention in pregnant women with obesity. Obesity (Silver Spring) 2016 Oct;24(10):2042-9. PMCID: PMC5084910
  • Glass AG, Leo MC, Haddad Z, Yousefi K, du Plessis M, Chen C, Choeurng V, Abdollah F, Robbins B, Ra S, Richert-Boe KE, Buerki C, Pearson K, Davicioni E, Weinmann S. Validation of a genomic classifier for predicting post-prostatectomy recurrence in a community-based healthcare setting. J Urol 2016 Jun;195(6):1748-53.
  • Clarke G, DeBar LL, Pearson JA, Dickerson JF, Lynch FL, Gullion CM, Leo MC. Cognitive Behavioral Therapy in Primary Care for Youth Declining Antidepressants: A Randomized Trial. Pediatrics 2016 May;137(5). PMCID: PMC4845864
  • Leo MC, McMullen C, Wilfond BS, Lynch FL, Reiss JA, Gilmore MJ, Himes P, Kauffman TL, Davis JV, Jarvik GP, Berg JS, Harding C, Kennedy KA, Simpson DK, Quigley DI, Richards CS, Rope AF, Goddard KA. Patients' ratings of genetic conditions validate a taxonomy to simplify decisions about preconception carrier screening via genome sequencing. Am J Med Genet A 2016 Mar;170(3):574-82. PMCID: PMC4824299
  • Yarborough BJ, Leo MC, Yarborough MT, Stumbo S, Janoff SL, Perrin NA, Green CA. Improvement in Body Image, Perceived Health, and Health-Related Self-Efficacy Among People With Serious Mental Illness: The STRIDE Study. Psychiatr Serv 2016 Mar 1;67(3):296-301.
  • Nguyen-Truong CK, Leo MC, Lee-Lin F, Gedaly-Duff V, Nail LM, Gregg J, Le TV, Tran T. Adaptation and testing of instruments to measure cervical cancer screening factors among vietnamese immigrant women. J Transcult Nurs 2015 May;26(3):244-53.[Epub 2014 Apr 1]
  • Leo MC, Lindberg N, Vesco KK, Stevens VJ. Validity of medical chart weights and heights for obese pregnant women. eGEMs 2014;2(1):1051. PMCID: PMC4371469

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