ResearchResearch AreasCardiovascular DiseasePROMPT

PROMPT: Medication Support Program

PROMPT is a program that helps high-risk patients with existing diabetes or atherosclerotic cardiovascular disease take and refill:

  • Angiotensin converting enzyme inhibitors (ACEIs)
  • Angiotensin receptor blockers (ARBs)

Key Features of PROMPT

  • Automated refill reminder calls using interactive voice recognition (IVR) technology, that offer to transfer the patient to a pharmacy line where they can order their refill or talk with a pharmacy technician
  • Mailed reminder letters to patients if refill is >60 days overdue
  • Live outreach phone call if refill is >90 days overdue
  • Bi-monthly educational mailings
  • Electronic medical record (EMR) documentation of PROMPT support


The program was tested by The Center for Health Research at Kaiser Permanente in 2012 in three of its regions (NW, HI, and GA). This was conducted as a pragmatic clinical trial (PATIENT study) funded by the Agency for Healthcare Research and Quality. Outcomes of the trial included:

  • Medication adherence (defined from pharmacy dispensing records using modified Proportion of Days Covered measure)
  • Lipid and blood pressure levels
  • Health status
  • CVD-related emergency department visits and hospitalizations
  • Cost-effectiveness
  • Implementation feasibility



Vollmer et al. Improving Adherence to Cardiovascular Disease Medications with Information Technology, The American Journal of Managed Care, 2014.

  Link to Publication


Promoting Adherence to Improve Effectiveness of Cardiovascular Disease Therapies (PATIENT)

David Smith, PhD, Interregional Medication Adherence Committee, June 17, 2013

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