Greg Clarke, PhD, has focused much of his research on the prevention and treatment of depression, anxiety, and insomnia in both adults and youth, as well as population-level mental health improvement through the use of e-health interventions (e.g., websites, smartphone apps).

Dr. Clarke has been the principal investigator and co-investigator on over a dozen grants funded by the National Institute of Mental Health, conducting controlled-outcome trials of depression treatment and prevention in at-risk populations. Some of his most recent controlled trials have examined approaches to preventing suicidal behaviors and deaths in at-risk youth and adults, treating insomnia in depressed youth to improve mood outcomes, medication and psychotherapy treatment of depression in adolescents who have failed to respond to an initial antidepressant medication, simultaneous insomnia treatment and antidepressant medication for depressed youth, and Internet self-care programs for depressed adults and adolescents.

Dr. Clarke received his PhD in clinical psychology from the University of Oregon in 1985 and has conducted mental health research for more than 30 years.

Selected Current Studies

  • An Efficacy-Effectiveness Trial of Stepped Care for Suicide Prevention in Youth—STEP2Health (NIMH)
  • Pragmatic Suicide Prevention Outreach Trial—SPOT (NIMH)
  • CBT-Insomnia Augmenting Usual Care SSRIs to Improve Youth Depression Outcomes—SleepWell (NIMH))
  • An Efficacy-Effectiveness Trial of Cognitive Bias Modification for Youth Anxiety—ReThink (NIMH)

Selected Publications

  • Dickerson JF, Lynch FL, Leo MC, DeBar LL, Pearson J, Clarke GN. Cost-effectiveness of cognitive behavioral therapy for depressed youth declining antidepressants. Pediatrics. 2018 Feb;141(2). pii: e20171969. PMCID: PMC5810604 [Available on 2019-02-01]
  • Brent DA, Brunwasser SM, Hollon SD, Weersing VR, Clarke GN, Dickerson JF, Beardslee WR, Gladstone TR, Porta G, Lynch FL, Iyengar S, Garber J. Effect of a cognitive-behavioral prevention program on depression 6 years after implementation among at-risk adolescents: A randomized clinical trial. JAMA Psychiatry. 2015 Nov;72(11):1110-8. PMCID: PMC4635056
  • Clarke G, McGlinchey EL, Hein K, Gullion CM, Dickerson JF, Leo MC, Harvey AG. Cognitive-behavioral treatment of insomnia and depression in adolescents: A pilot randomized trial. Behav Res Ther. 2015; 69:111-8. PMCID: PMC4418229
  • Garber J, Clarke GN, Weersing VR, Beardslee WR, Brent DA, Gladstone TR, DeBar LL, Lynch FL, D’Angelo E, Hollon SD, Shamseddeen W, Iyengar S. Prevention of depression in at-risk adolescents: A randomized controlled trial. JAMA. 2009 Jun 3; 301(21):2215-24. PMCID: PMC2737625
  • Clarke G, Kelleher C, Hornbrook M, Debar L, Dickerson J, Gullion C. Randomized effectiveness trial of an Internet, pure self-help, cognitive behavioral intervention for depressive symptoms in young adults. Cogn Behav Ther. 2009; 38(4):222-34. PMCID: PMC2829099
  • Brent D, Emslie G, Clarke G, Wagner KD, Asarnow JR, Keller M, Vitiello B, Ritz L, Iyengar S, Abebe K, Birmaher B, Ryan N, Kennard B, Hughes C, DeBar L, McCracken J, Strober M, Suddath R, Spirito A, Leonard H, Melhem N, Porta G, Onorato M, Zelazny J. Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: The TORDIA randomized controlled trial. JAMA. 2008 Feb 27; 299(8):901-13. PMCID: PMC2277341
  • Clarke G, Debar L, Lynch F, Powell J, Gale J, O'Connor E, Ludman E, Bush T, Lin EH, Von Korff M, Hertert S. A randomized effectiveness trial of brief cognitive-behavioral therapy for depressed adolescents receiving antidepressant medication. J Am Acad Child Adolesc Psychiatry. 2005 Sep; 44(9):888-98. PubMed PMID: 16113617
  • Clarke G, Eubanks D, Reid E, Kelleher C, O'Connor E, DeBar LL, Lynch F, Nunley S, Gullion C. Overcoming Depression on the Internet (ODIN) (2): A randomized trial of a self-help depression skills program with reminders. J Med Internet Res. 2005 Jun 21; 7(2):e16. PMCID: PMC1550641

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