David H. Smith, RPh, PhD


David Smith, PhD, RPh, studies the economic evaluation of medical interventions, drug safety and prescribing behavior,  and the natural history of disease. Current studies involve clinical and economic evaluation of opioid use initiatives, FDA-mandated drug safety studies, and heart failure interventions.

Dr. Smith received his pharmacy degree from the University of Washington. After completing his residency in general/clinical pharmacy, he worked as a clinical pharmacist in home care. He received an MHA in health services administration and a PhD in pharmacy outcomes research from the University of Washington and was a postdoctoral fellow at the Centre for Health Economics at University of York (UK). He is adjunct faculty at the University of Washington's School of Pharmacy and the Oregon State University College of Pharmacy.

Recent Publications

  • Smith DH, Kuntz J, DeBar L, Yang X, Petrik A, Reese K, Thorsness L A, Boardman D, Johnson ES. A randomized, pragmatic, pharmacist-led intervention reduced opioids following orthopaedic surgery. American Journal of Managed Care (accepted).
  • Smith DH, O'Keeffe-Rosetti M, Owen-Smith AA, Rand C, Tom J, Vupputuri S, Laws R, Waterbury A, Hankerson-Dyson DD, Yonehara C, Williams A, Schneider J, Dickerson JF, Vollmer WM. Improving Adherence to Cardiovascular Therapies: An Economic Evaluation of a Randomized Pragmatic Trial. Value Health. 2016 Mar-Apr;19(2):176-84. PubMed PMID: 27021751.
  • Smith DH; Johnson ES; Boudreau DM; Cassidy-Bushrow AE; Fortmann SP; Greenlee RT; Gurwitz JH; Magid DJ; McNeal CJ; Reynolds K; Steinhubl SR; Thorp M; Tom JO; Vupputuri S; VanWormer JJ; Weinstein J; Yang X; Go AS; Sidney S. Comparative Effectiveness of Statin Therapy in Chronic Kidney Disease and Acute Myocardial Infarction: A Retrospective Cohort Study. Am J Med. 2015 Jul 10. pii: S0002-9343(15)00581-1. doi: 10.1016/j.amjmed.2015.06.030. [Epub ahead of print]
  • Smith DH, Perrin N, Feldstein A, Yang X, Kuang D, Simon SR, Sittig DF, Platt R, Soumerai SB. The impact of prescribing safety alerts for elderly persons in an electronic medical record: an interrupted time series evaluation. Arch Intern Med 2006 May 22;166(10):1098-104.

Press Release

Pharmacist-Led Intervention at Kaiser Permanente Northwest Reduces Opioid Use Among Hip Replacement Surgery Patients

For patients who received targeted outreach, median opioid use was about half that of patients who received only usual care.

Nov 15, 2018


Researchers and Pharmacists Team Up to Combat Opioid Overuse

Scientists at the Center for Health Research recently partnered with KP pharmacists to test a program to curb prolonged opioid use, as part of an FDA-funded clinical trial.

May 4, 2017

Press Release

Automated Reminders Improve Medication Adherence and Cholesterol Control

People who received automated reminders were more likely to refill their blood pressure and cholesterol medications, according to a study published today in a special issue of the American Journal of Managed Care.

Nov 17 2014